Curtis D Klaassen Selected Research

Multidrug Resistance-Associated Proteins

10/2019	Identification and Characterization of Efflux Transporters That Modulate the Subtoxic Disposition of Diclofenac and Its Metabolites.
1/2018	Alteration of Bile Acid and Cholesterol Biosynthesis and Transport by Perfluorononanoic Acid (PFNA) in Mice.
1/2012	Effect of graded Nrf2 activation on phase-I and -II drug metabolizing enzymes and transporters in mouse liver.
3/2010	Xenobiotic, bile acid, and cholesterol transporters: function and regulation.
9/2008	Prominent expression of xenobiotic efflux transporters in mouse extraembryonic fetal membranes compared with placenta.
2/2008	Xenobiotic transporters: ascribing function from gene knockout and mutation studies.
5/2006	Induction of hepatic transporters multidrug resistance-associated proteins (Mrp) 3 and 4 by clofibrate is regulated by peroxisome proliferator-activated receptor alpha.

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Curtis D Klaassen Research Topics

Disease

10	Neoplasms (Cancer) 01/2020 - 07/2002
10	Breast Neoplasms (Breast Cancer) 10/2019 - 01/2005
10	Cholestasis 01/2018 - 09/2004
8	Inflammation (Inflammations) 01/2016 - 12/2008
8	Body Weight (Weight, Body) 10/2015 - 02/2002
7	Necrosis 01/2015 - 02/2002
5	Intrahepatic Cholestasis 07/2009 - 07/2004
4	Acute-Phase Reaction 01/2016 - 06/2004
4	Obesity 10/2015 - 01/2012
4	Hypercholesterolemia 02/2012 - 05/2006
3	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2022 - 01/2012
3	Liver Neoplasms (Liver Cancer) 01/2020 - 01/2010
3	Fatty Liver 07/2014 - 06/2010
3	Infections 02/2012 - 10/2011
2	Liver Diseases (Liver Disease) 01/2022 - 07/2013
2	Hepatocellular Carcinoma (Hepatoma) 01/2021 - 01/2005
2	Hyperbilirubinemia 01/2020 - 01/2018
2	Dyslipidemias (Dyslipidemia) 01/2019 - 01/2012
2	Feminization 01/2018 - 01/2014
2	Drug-Related Side Effects and Adverse Reactions 02/2016 - 07/2014
2	Acquired Immunodeficiency Syndrome (AIDS) 01/2016 - 04/2010
2	Hemorrhage 01/2015 - 08/2012
2	Tuberculosis (Tuberculoses) 01/2014 - 04/2013
2	Hypertension (High Blood Pressure) 02/2012 - 10/2011
2	Hyperglycemia 01/2012 - 04/2010
2	Carcinogenesis 05/2011 - 09/2004
2	Ischemia 01/2008 - 03/2007
1	Acne Vulgaris 01/2022
1	Hyperferritinemia 01/2022
1	Iron Overload 01/2022
1	Thalassemia 01/2022
1	Dehydration (Water Stress) 09/2020
1	Hereditary Hyperbilirubinemia (Rotor Syndrome) 01/2020
1	Rhabdomyolysis 01/2020
1	Myalgia 01/2020
1	Muscular Diseases (Myopathy) 01/2020
1	Gout 11/2019

Drug/Important Bio-Agent (IBA)

14	Proteins (Proteins, Gene)FDA Link 10/2019 - 03/2002
11	Bile Acids and Salts (Bile Acids)IBA 01/2022 - 05/2006
9	EnzymesIBA 01/2019 - 09/2004
9	Messenger RNA (mRNA)IBA 01/2018 - 03/2002
7	Multidrug Resistance-Associated ProteinsIBA 10/2019 - 05/2006
6	CholesterolIBA 01/2018 - 06/2004
6	XenobioticsIBA 01/2016 - 07/2002
5	Peptides (Polypeptides)IBA 05/2018 - 02/2008
5	Insulin (Novolin)FDA Link 01/2015 - 04/2010
4	AnionsIBA 01/2018 - 02/2008
4	Pharmaceutical PreparationsIBA 02/2016 - 06/2004
4	Pregnenolone Carbonitrile (PCN)IBA 01/2016 - 03/2002
4	LipopolysaccharidesIBA 01/2015 - 07/2004
4	Organic Anion TransportersIBA 07/2014 - 02/2008
3	IronIBA 01/2022 - 09/2008
3	Alanine Transaminase (SGPT)IBA 01/2018 - 08/2012
3	Glucose (Dextrose)FDA LinkGeneric 11/2012 - 04/2010
3	BerberineIBA 02/2012 - 10/2011
3	ATP-Binding Cassette Transporters (ABC Transporters)IBA 03/2010 - 01/2005
2	Oxidoreductases (Dehydrogenase)IBA 01/2021 - 01/2006
2	NAD (NADH)IBA 01/2021 - 01/2006
2	quinone (benzoquinone)IBA 01/2021 - 01/2006
2	ArsenicIBA 01/2020 - 01/2004
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2020 - 07/2014
2	Uric Acid (Urate)IBA 11/2019 - 11/2009
2	Member 11 Subfamily B ATP Binding Cassette TransporterIBA 01/2018 - 03/2010
2	sodium-bile acid cotransporterIBA 01/2018 - 07/2004
2	1,4- bis(2- (3,5- dichloropyridyloxy))benzeneIBA 01/2016 - 05/2009
2	PhalloidineIBA 01/2015 - 05/2008
2	ChemokinesIBA 10/2014 - 01/2014
2	CytokinesIBA 10/2014 - 01/2014
2	Isoniazid (Ftivazide)FDA LinkGeneric 01/2014 - 04/2013
2	Interleukin-6 (Interleukin 6)IBA 01/2014 - 01/2005
2	Fatty Acids (Saturated Fatty Acids)IBA 01/2014 - 06/2004
2	LipidsIBA 01/2013 - 01/2012
2	Blood Glucose (Blood Sugar)IBA 01/2013 - 11/2012
2	fibroblast growth factor 21IBA 11/2012 - 10/2011
2	CadmiumIBA 08/2012 - 11/2003
2	Glutathione (Reduced Glutathione)IBA 06/2012 - 10/2011
2	Streptozocin (Streptozotocin)FDA Link 01/2012 - 04/2010
2	Triglycerides (Triacylglycerol)IBA 01/2012 - 10/2011
2	Adenosine Triphosphate (ATP)IBA 01/2012 - 03/2010
2	CarcinogensIBA 12/2011 - 12/2007
2	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 05/2011 - 01/2010
2	Choline (Choline Chloride)IBA 06/2010 - 01/2009
2	Methionine (L-Methionine)FDA Link 06/2010 - 01/2009
2	Subfamily B ATP Binding Cassette TransporterIBA 03/2010 - 09/2008
2	Diethylhexyl Phthalate (DEHP)IBA 01/2010 - 02/2002
2	Phenobarbital (Luminal)FDA Link 01/2010 - 05/2009
2	Lithocholic AcidIBA 07/2009 - 05/2009
2	MetalsIBA 02/2008 - 11/2003
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 03/2007 - 01/2005
1	Hygroscopic AgentsIBA 01/2022
1	AstringentsIBA 01/2022
1	Fibroblast Growth Factors (Fibroblast Growth Factor)IBA 01/2022
1	GW 4064IBA 01/2022
1	saikosaponin DIBA 09/2020
1	SuspensionsIBA 09/2020
1	sodium arsenite (sodium metaarsenite)IBA 01/2020
1	BilirubinIBA 01/2020
1	MicroRNAs (MicroRNA)IBA 01/2020
1	Drinking WaterIBA 01/2020

Therapy/Procedure

3	Therapeutics 04/2013 - 05/2010